What is Paroxetine ?
Paroxetine is an antidepressant that belongs to a group of drugs called SSRIs(selective serotonin reuptake inhibitors).
Paroxetine affects chemicals in the brain that may be unbalanced in patients with anxiety, depression and other disorders.
Paroxetine treats depression, including major depressive disorder.
Paroxetine is also taken for the treatment of panic disorder, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).
You should know about Paxil;
You should not use this if you are also taking
pimozide or thioridazine.
Do not take Paxil within 14 days before or 14 days after you have used an MAO inhibitor, such as
isocarboxazid
linezolid
methylene blue injection
phenelzine
rasagiline
selegiline
tranylcypromine.
Some young person have thoughts about suicide when first using an antidepressant. Stay alert to changes in your mood. Report any new symptoms to your doctor.
Seek medical attention right away if you have symptoms such as:
agitation
hallucinations
muscle stiffness
twitching
loss of coordination
dizziness
warmth or tingly feeling
nausea
vomiting
diarrhea
fever
Cautions before taking this medicine;
You do not use Paxil if you are allergic to paroxetine, or if you are also using pimozide or thioridazine.
Caution about Disease;
Call your doctor to make sure that Paxil is safe for you if you have;
heart disease
high blood pressure or a stroke
liver or kidney disease
a bleeding or blood clotting disorder
seizures or epilepsy
bipolar disorder (manic depression)
drug addiction
suicidal thoughts
narrow-angle glaucoma
low levels of sodium in your blood
Caution about MHO inhibitor;
Do not use an MAO inhibitor within 14 days before or 14 days after you take Paxil.
A risky drug interaction could occur.
MAO inhibitors are;
isocarboxazid
linezolid
phenelzine
rasagiline
selegiline
tranylcypromine
You must wait at least 14 days after stopping to take Paxil before you start using an MHO inhibitor.
Caution about medicine;
Tell your doctor to make sure if you are taking;
lsd stimulant medicine
opioid medicine
herbal products
medicine for depression
mental illness
Can I take Paxil during pregnancy?
Taking Paxil during pregnancy may cause serious lung problems or other complications in the baby.
However, you should have a relapse of depression if you stop taking your antidepressant.
You should not breastfeed while taking this medicine.
Is Paxil approved for children?
No, Paxil is not approved for use by anyone younger than 18 years old.
How should I take Paxil?
Use Paxil exactly as prescribed by your doctor.
Move the Paxil oral suspension (liquid) before you measure a dose. Take the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Do not use a kitchen spoon.
It can take up to 4 weeks before your symptoms improve.
Can I stop this medicine suddenly?
Do not stop taking Paxil suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop taking this medicine.
Where can I store this medicine?
Store it at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take this medicine as soon as you can.
Skip the missed dose of Paxil if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention because overdose of paroxetine can be fatal.
Side effects of Paxil;
Get emergency medical help if you have signs of an allergic reaction to Paxil (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction.
Some Serious side effects;
Call your doctor immediately if you have;
racing thoughts
blurred vision
unusual bone pain
changes in weight or appetite
easy bruising
severe nervous system reaction
low levels of sodium in the body - headache
Some common side effects;
vision changes;
weakness, drowsiness
sweating
anxiety
sleep problems (insomnia);
loss of appetite
dry mouth
infection
headache
This is not a full list of side effects and others may occur.
Paroxetine 20 mg
Chemical formula – C19H20FNO3
Drug class - selective serotonin reuptake inhibitors(SSRIs)
Trade name - Paxil
Uses -
Used mainly for mood elevation purpose in mood depressive disorder.
Also widely used in phobia, obsessive compulsive disorder, anxiety.
Also used in posttraumatic stress, pre menstrual dysphoric disorder.
Also showed effect in premature ejaculation.
Advantage -
Relative Safe drug then other so first line of treatment in depressive disorder.
Wide range of uses and effective in multiple mood related disorder.
No sedating effect.
Better than TCAs(Tricyclic antidepressants)
Do not interfere with cognitive psychomotor function.The drug is metabolized in liver , absorbed in GI tract , excretion is through kidney and faeces , half life is 20 to 22 hours.
Dose -
10 to 40 mg .
Taken orally.